Use of Arabidopsis thaliana as a model to understand specific carcinogenic events: Comparison of the molecular machinery associated with cancer-hallmarks in plants and humans
Published in Heliyon, 2023
Recommended citation: Clavijo-Buriticá, D. C., Sosa, C. C., Heredia, R. C., Mosquera, A. J., Álvarez, A., Medina, J., & Quimbaya, M. (2023). Use of Arabidopsis thaliana as a model to understand specific carcinogenic events: Comparison of the molecular machinery associated with cancer-hallmarks in plants and humans. Heliyon, 9(4). https://doi.org/10.1016/j.heliyon.2023.e15367
Abstract
This study evaluates Arabidopsis thaliana as a complementary model for specific carcinogenic processes using the cancer-hallmarks framework as a systems-level comparison between plants and humans. Instead of restricting analysis to isolated pathways, we integrate functional, network, and machine-learning perspectives to identify conserved mechanisms relevant to neoplastic transformation. The results highlight five cancer hallmarks with overlapping biological processes across species and propose candidate regulators and modules for further validation. Our findings support Arabidopsis as a focused comparative model for selected cancer properties and provide a structured route to prioritize mechanistic studies in translational cancer research.